mouse.IsPressedIn(x) vs clickable_stimuly

I have a trial with a button image, and I want to record if and when it is being pressed with the mouse. I am not sure if to define this image as a clickable_stimuly in the mouse object, or rather write a code that checks each frame if mouse.IsPressedIn(image)? If I use the code - should I just leave the clickable_stimuly tab empty?

What are the differences between the methods? When should I use each?

Thank you!

Hi @Gil_Shner_Livne
I have to do something similar, do you have a recommendation that worked for you?
Thank you so much!

In case someone else needs help with this, I can recommend this comment: Images as buttons on the screen - #9 by Michael