mouse.IsPressedIn(x) vs clickable_stimuly

I have a trial with a button image, and I want to record if and when it is being pressed with the mouse. I am not sure if to define this image as a clickable_stimuly in the mouse object, or rather write a code that checks each frame if mouse.IsPressedIn(image)? If I use the code - should I just leave the clickable_stimuly tab empty?

What are the differences between the methods? When should I use each?

Thank you!