I'm reposting because I have a bit more info (old post linked below).
My problem is that most of the time, mouse clicks are missed. I just tried running the shapeContains.py demo and found that, while I can see the cursor move, the "buffer zone" that should follow the cursor will typically stop following the mouse for 1-3s. During this time, mouse clicks are completely missed and the mouse cursor is not registered as being near or in the shape. Even when there are issues in the psychopy experiment window, I can click on the coder window as well as anywhere else on my desktop without an issue.
None of these issues occur on my own Mac laptop or my office Mac desktop, only on PC (running Windows 10 enterprise).
Our IT guy has no idea what the issue might be. I'm hoping I can get pointed in the right direction here.