Hello,
General purpose communication with serial devices using Python is usually done with the PySerial library.
https://pythonhosted.org/pyserial/
Something like this will write a byte to the port and read the response.
import serial
def main():
# open the port
port = serial.Serial("COM1", 9600)
port.write('a')
port.flush()
while not port.inWaiting():
print(port.readline())
port.close()
return 0
if __name__ == "__main__":
main()