By screen reader accessible- I mean that one of my sample groups are participants who are blind and use screen readers to access the computer. Screen reader users will solely use the keyboard to interact with the computer, and some sites/software warrant mouse use or are not well developed to be accessed with a screen reader- so the participant would not be able to complete the tasks in that program. I had seen another post (Accessibility of online experiments) where they described some barriers, so that makes the PsychoPy stimuli concerning to use for my experiment.
What is OBS? I do think after the information you provided about PsychoPy being unhappy with other programs, I will need to consider not using it afterall.
I appreciate your feedback!